Automated CO2 Extraction | Core Separations

Core |ESS Extraction Screening System

The ESS (Extraction Screening System) is designed for users who want to screen multiple supercritical conditions to optimize their processes. It is also suitable for preparing samples for HPLC or GC analysis, such as in food safety and pesticide analysis. The ESS features 8 extraction vessels (10mL, 25mL, or 50mL) and can be programmed to automatically collect each extract into separate collection bottles under various conditions. Capable of generating pressures up to 10,000 psi (689 bar) and temperatures up to 100°C, this versatile system is suitable for even the most demanding extractions.

Information

Application

Options

Features

Specification

Sample Preperation

Preparing samples for analysis is key for ensuring results are both repeatable and reproducible. Correct sample preparation also helps to improve sensitivity and prolongs column life by removing unwanted contaminants that may interfere with the analysis. The ESS can be used with either CO2, CO2 and a modifier or just pure solvent to effectively prepare any solid sample ready for analysis. Samples can be prepared in duplicate using the dual vessel arrangement. Every 2 vessels are in one of the 4 heated zones ensuring each dual pair is heated to the same temperature. This makes the ESS the ideal choice for sample preparation capable or operating under a wide variety of conditions.

Extraction Screening

Optimising an extraction, when using CO2 as a supercritical fluid can be time consuming when exploring both the effect of varying the pressure and temperature on the yield and purity. This optimisation can be greatly improved using the ESS which can be programmed with up to 8 individual conditions to help quickly screen for the best results.

Why not read about some of the most common applications below?

Soil Analysis

Sample Preparation

Supercritical CO2 extraction is a powerful method for analysing toxins and pesticides in soil samples. It offers several advantages, including high selectivity, efficiency, and safety. Consequently, it has become an increasingly popular technique in environmental analysis and monitoring.

Food Analysis

Sample Preparation

Dioxins and pesticides are toxic compounds that can accumulate in the food chain and pose a risk to human health if consumed in high levels. Supercritical CO2 extraction can be employed to extract these compounds for analysis, ensuring that food meets required safety standards by accurately determining their levels.

Pharmaceutical Analysis

Sample Preparation

Supercritical CO2 can be utilized in quality control within the pharmaceutical industry. Active Pharmaceutical Ingredients (APIs) can be extracted from the tablet matrix and then analysed using various techniques to determine their purity and potency.

Optimisation Studies

Extraction Screening

Optimizing supercritical CO2 conditions is crucial for developing an effective extraction process for any application. Extraction time is a key parameter that can be adjusted to increase the yield of desired compounds. The ESS can be utilised to identify the optimal extraction conditions, thereby maximizing the yield of the target compounds.

Selectivity Screening

Extraction Screening

The ESS can be employed to evaluate the effectiveness of supercritical CO2 in extracting various levels of bio-active compounds from natural products. It allows for the investigation of extraction efficiency under specific conditions, enabling the separation of different molecules of interest.

Plant Evaluation

Extraction Screening

Evaluating different plant breeds is crucial for exploring the varying concentrations of bioactive compounds in natural products. The multivessel screening available on the ESS allows for quick and effective examination of different plant breeds and the concentrations of their bio-active compounds.

Automated Extraction

Extractions run sequentially over the 8 positions controlled by the SFX software. Automated valving allow for unattended operation.

Independent Conditions

System runs sequential through the 8 vessel positions allowing the user to define different pressures for each vessel, The temperature is controlled through 4 heater zones allowing for each vessel pair to be controlled to the same temperature.

Automated Collection

Each vessel is paired with a collection position allowing each individual extraction to be isolated and collected in its own bottle.

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Frequently Asked
Questions

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1. What is the ESS?

Extraction Screening System (ESS) is an automated high-pressure system designed for the preparation of various samples for analysis. It is equipped with eight extraction vessels that can operate at pressures up to 600 bar and temperatures up to 80°C. As an alternative to accelerated solvent extraction systems.

2. How does the ESS extract my product?

ESS uses either pure CO2 or a mixture of CO2 and co-solvents as the extraction medium. This approach is considered more selective, enabling the isolation of different compound classes compared to traditional solvent-based methods.

3. What are the extraction vessel sizes available?

The ESS is a versatile instrument that can be configured with 8 vessels, arranged in 4 bays of 2 vessels each. It offers flexibility in vessel size, allowing for the use of 10, 25, or 50 mL vessels, depending on the sample size being processed. This makes the system ideal for a variety of process.

4. What are the Advantages of the ESS?

ESS significantly reduces the extraction time, allowing for quicker processing of samples. Additionally, the method requires minimal sample manipulation, preserving the integrity of the materials being extracted. Another key benefit is the lower solvent consumption, which not only makes the process more environmentally friendly but also leads to higher purity in the final extracts. As a result, ESS is an effective and cleaner alternative for producing high-quality extracts across various applications, from pharmaceuticals to food products.

Core |ESS Extraction Screening System

Sample Preperation